Can a man with klinefelter’s syndrome get breast cancer


Men with Klinefelter syndrome are more likely to get breast cancer than other men. Having this condition can increase the risk anywhere between 20 – 60 times the risk of a man in the general population.Apr 27, 2018

What cancers can Klinefelter syndrome cause?

Klinefelter’s syndrome is associated with an increased risk of developing lung cancer, breast cancer, and non-Hodgkin lymphoma, and with a lower risk of prostate cancer, reports a UK study (J Natl Cancer Inst 2005; 97: 1204–10).

What men are at risk for breast cancer?

A man’s risk for breast cancer is higher if any of his close relatives have had breast cancer, and especially if any male relatives have had the disease. Men who inherit certain genetic mutations from their mothers or fathers have a higher risk of developing breast cancer.

Is Klinefelter syndrome cancerous?

Conclusions: These results support a hormonal etiology for breast cancer in men and for prostate cancer and suggest that men with Klinefelter syndrome may be at substantially elevated risks for non-Hodgkin lymphoma, breast cancer, and, perhaps, lung cancer.

What causes breast cancer in men?

In men, mutations in the BRCA1 and BRCA2 genes can increase the risk of breast cancer, high-grade prostate cancer, and pancreatic cancer. If genetic testing shows that you have a BRCA1 or BRCA2 gene mutation, your doctor will explain what you should do to find cancer early, if you get it.

Can a male develop breast cancer?

Breast cancer occurs mainly in women, but men can get it, too. Many people do not realize that men have breast tissue and that they can develop breast cancer. Cells in nearly any part of the body can become cancer and can spread to other areas.

What is the life expectancy of a person with Klinefelter syndrome?

Prognosis for Klinefelter Syndrome In general, life expectancy is normal. Some research has found that life expectancy for men with the condition may be a year or two less than those without it because of other health problems linked to Klinefelter.

What is the quality of life with Klinefelter syndrome?

Quality of life is significantly impaired in men with Klinefelter Syndrome, most likely due to discrimination and the presence of somatic and mental health problems. A multidisciplinary approach of healthcare providers might help to provide adequate counselling and treatment to improve quality of life.

Does Klinefelter syndrome cause mental retardation?

Klinefelter syndrome (KS) has not typically been associated with mental retardation (MR), however, in recent years a growing body of evidence suggested that KS boys often experience language deficits and academic difficulties.

How is male breast cancer diagnosed?

A biopsy is the only definitive way to make a diagnosis of breast cancer. During a biopsy, your doctor uses a specialized needle device guided by X-ray or another imaging test to extract a core of tissue from the suspicious area.

How long can you live with male breast cancer?

5-year relative survival rates for breast cancer in menSEER stage5-year relative survival rateLocalized95%Regional83%Distant19%All SEER stages combined82%Mar 1, 2022

Is Klinefelter syndrome intersex?

Other intersex conditions, including the last four conditions listed above—complete androgen insensitivity, Klinefelter syndrome, Turner syndrome, and vaginal agenesis—usually do not result in ambigu- ous genitals and may not be recognized at birth.

What is Klinefelter syndrome caused by?

Klinefelter syndrome is caused by an additional X chromosome. This chromosome carries extra copies of genes, which interfere with the development of the testicles and mean they produce less testosterone (male sex hormone) than usual.

Is there any treatment for Klinefelter syndrome?

Testosterone replacement therapy. Starting at the time of the usual onset of puberty, testosterone replacement therapy can be given to help stimulate changes that normally occur at puberty, such as developing a deeper voice, growing facial and body hair, and increasing muscle mass and sexual desire (libido).

What treatments are available for Klinefelter syndrome?

How is Klinefelter syndrome treated? Males with Klinefelter syndrome can be given testosterone, a hormone needed for sexual development. If treatment is started around the age of puberty, it can help boys with the sexual development of their bodies. Testosterone is given by injection or through a skin patch or gel.

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