A national cancer institute tamoxifen and breast cancer relative risk


Background: Initial findings from the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial (P-1) demonstrated that tamoxifen reduced the risk of estrogen receptor–positive tumors and osteoporotic fractures in women at increased risk for breast cancer.


When it comes to preventive uses, tamoxifen has a good track record of substantially reducing new or recurrent cancer in women with high levels of cancer risk. Another positive is its cost. As an older drug, tamoxifen is available in generic form, so it is likely to be less expensive than some newer medications.


Some women lose weight on tamoxifen. Many European countries no tamoxifen for weight loss allow this practice in any meat tanoxifen. The oncologist should be able to provide a healthy daily calorie goal for you — stick to it. It is also given to select women with active disease spread throughout the body metastatic disease.


Tamoxifen comes as a tablet to take by mouth. Tamoxifen is usually taken once or twice a day with or without food. Take tamoxifen at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain anything you do not understand. Take tamoxifen exactly as directed.


Tamoxifen lowers the risk of [ 91 ]:

  • Breast cancer recurrence
  • Breast cancer in the opposite breast
  • Death from breast cancer

Does tamoxifen really work?

Does tamoxifen cause weight loss?

When to take tamoxifen?

How effective is tamoxifen?


How much does tamoxifen reduce the risk of breast cancer?

Prophylactic use of tamoxifen over five years reduces the incidence of breast cancer by 38% in healthy women with a high risk of developing the disease, a study published in the Lancet says (2003;361:296-300).

Can you get breast cancer while on tamoxifen?

While tamoxifen can lower the chance of hormone receptor-positive breast cancer coming back (as well as the risk of getting a second breast cancer), it can increase the risk of uterine cancer (endometrial cancer and uterine sarcoma).

How common are blood clots with tamoxifen?

The annual rate of deep vein thrombosis in tamoxifen users was 1.34 per 1000 women.

Is tamoxifen worth the risks?

Most experts agree that tamoxifen and raloxifene should not be used to reduce breast cancer risk in women who: Have a higher risk of serious blood clots* Are pregnant or planning to become pregnant.

What type breast cancer has the highest recurrence rate?

Research suggests that estrogen receptor-positive breast cancer is more likely to come back more than five years after diagnosis.

What happens after taking tamoxifen for 5 years?

Women who took tamoxifen for 5 years had a 17 percent lower risk of cancer recurrence and a 9 percent lower risk of death from breast cancer than women who took tamoxifen for only 2 years. They also had a 30 percent lower risk of developing cancer in the contralateral (other) breast.

Does tamoxifen cause aging?

Aging may be associated with concentrations of tamoxifen and its metabolites in breast cancer patients.

What can I take instead of tamoxifen?

The most popular alternative to tamoxifen is an aromatase inhibitor, such as Arimidex (anastrozole) and Aromasin (exemestane). Other SERMs, such as Evista (raloxifene), and estrogen-receptor antagonists, such as Faslodex (fulvestrant), may also be prescribed instead of tamoxifen.

Does tamoxifen affect your teeth?

Conclusions: While tamoxifen did not affect the dental and periodontal condition, AIs medication adversely affected the dental and periodontal condition by more tooth loss and higher CAL.

Does tamoxifen shorten your life?

Tamoxifen as a breast cancer prevention drug has little impact on overall mortality rates for most “high-risk” women, according to a new study. Tamoxifen as a breast cancer prevention drug has little impact on overall mortality rates for most “high-risk” women, according to a new study.

What are the long term effects of taking tamoxifen?

Tamoxifen can have side effects, including hot flashes, fatigue, and an increased risk of blood clots and endometrial cancer….Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival.5 Years10 YearsRisk of Recurrence25.1 percent21.4 percent1 more row•Mar 20, 2013

Why should I stop taking tamoxifen?

Some may stop because of common side effects, such as hot flashes, vaginal dryness and mood swings. Others may worry about tamoxifen’s rare side effects, including blood clots and increased risk of uterine cancer. Some women might stop in order to become pregnant, since tamoxifen can damage a fetus.

Does tamoxifen stop cancer spreading?

For women with hormone-positive breast cancer that has spread to other parts of the body, tamoxifen can often help slow or stop the growth of the cancer, and might even shrink some tumors.

What is the success rate of tamoxifen?

(Some women, however, receive tamoxifen followed by an aromatase inhibitor over a 5-year period.)…Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival.5 Years10 YearsRisk of Recurrence25.1 percent21.4 percentRisk of Death from Breast Cancer15.0 percent12.2 percentMar 20, 2013

How much does tamoxifen reduce risk of recurrence?

Doctors have long known that five years of tamoxifen reduces recurrence by about half during treatment and by nearly a third over the next five years. Aromatase inhibitors, which work only in postmenopausal women, are even more effective than tamoxifen at reducing recurrence and death from breast cancer.

How quickly can tamoxifen cause uterine cancer?

After 2-5 years of receiving tamoxifen, the risk for developing uterine cancer doubled and after 5 years of tamoxifen use the risk for developing uterine cancer increased by a factor of 7.

What is the average American woman’s risk of developing breast cancer during her lifetime?

Based on current incidence rates, 12.9% of women born in the United States today will develop breast cancer at some time during their lives ( 1 )…

What is the average American woman’s risk of being diagnosed with breast cancer at different ages?

Many women are more interested in the risk of being diagnosed with breast cancer at specific ages or over specific time periods than in the risk of…

How has the risk of being diagnosed with breast cancer changed in recent years?

For a woman born in the 1970s in the United States, the lifetime risk of being diagnosed with breast cancer, based on breast cancer statistics fr…

What are hormones and hormone receptors?

Hormones are substances that function as chemical messengers in the body. They affect the actions of cells and tissues at various locations in the…

What is hormone therapy?

Hormone therapy (also called hormonal therapy, hormone treatment, or endocrine therapy) slows or stops the growth of hormone-sensitive tumors by bl…

What types of hormone therapy are used for breast cancer?

Several strategies are used to treat hormone-sensitive breast cancer: Blocking ovarian function: Because the ovaries are the main source of est…

How is hormone therapy used to treat breast cancer?

There are three main ways that hormone therapy is used to treat hormone-sensitive breast cancer: Adjuvant therapy for early-stage breast cancer: Ta…

Can hormone therapy be used to prevent breast cancer?

Yes. Most breast cancers are ER positive , and clinical trials have tested whether hormone therapy can be used to prevent breast cancer in women w…

What are the side effects of hormone therapy?

The side effects of hormone therapy depend largely on the specific drug or the type of treatment ( 7 ). The benefits and harms of taking hormone th…

Can other drugs interfere with hormone therapy?

Certain drugs, including several commonly prescribed antidepressants (those in the category called selective serotonin reuptake inhibitors , or…

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